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I think this thread hook could be improved.
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I think this thread hook could be improved.
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2/n Il dit: "Si nous voulons passer de la pandémie à l'endémie, nous devrons à un moment donné accepter que la vaccination, l'infection naturelle ou une combinaison des deux n'offrent pas de protection à long terme contre les maladies bénignes."
= Paul rejette les pass vaccinaux.
3/n Il dit aussi: "Comme les rappels ne sont pas sans risque, nous devons préciser quels groupes en bénéficient le plus. Par exemple, les hommes âgés de 16 à 29 ans courent un risque accru de myocardite causée par les vaccins à ARNm."
= Paul rejette les boosters pour tous.
4/n Il dit enfin: "Et tous les groupes d'âge sont exposés au problème théorique du "péché antigénique originel", soit une capacité réduite à répondre à un nouvel immunogène parce que le système immunitaire est resté bloqué sur l'immunogène originel."
Ce point est important.
5/n Jusqu'à présent, nous avions un indice de la possible pertinence du "péché antigénique originel" pour les vaccins covid avec une étude sur des primates qui montrait qu'un booster spécifique Omicron n'apportait pas de bénéfice:
biorxiv.org/content/10.1101/2022.02.03.479037v1
6/n Plus récent, ce preprint basé sur les patients de l'ECR de Moderna le confirme en montrant que les vaccinés peinent à produire des anticorps anti-N après infection (probabilités de séropositivité anti-N 13,67 fois plus élevées dans le groupe placebo).
medrxiv.org/content/10.1101/2022.04.18.22271936v1
7/n En français courant, les vaccinés (primates) ne bénéficient pas d'un booster spécifique Omicron et les vaccinés (humains) produisent moins facilement des anticorps N après infection: ce sont deux signes que leur immunité a tendance à rester "bloquée" sur la spike vaccinale.
8/n Cela implique selon Paul que leur système immunitaire aura tendance à être moins efficace face à certains variants. Geert Vanden Bossche, lui, redoute également un plus grand risque de réinfection rapide et, surtout, à terme, de formes graves:
twitter.com/GabinJean3/status/1509808026642833412?s=20
9/9 Pendant ce temps, les autorités sanitaires continuent leur course aux boosters pour tous et aux obligations vaccinales futures, tandis que des (vrais?) comptes de mère américaines militent pour le vaccin des bébés.
C'est de l'irresponsabilité ?
Non, c'est de la Scienceᵀᴹ.